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Article

Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?

Experimental cell research - 1 Sept 1995

von Zglinicki T, Saretzki G, Döcke W, Lotze C

Abstract excerpt

Mild oxidative stress as exerted by culture of human WI-38 fibroblasts under 40% oxygen partial pressure blocks proliferation irreversibly after one to three population doublings. Hyperoxically blocked cells are similar to senescent ones in terms of general morphology and lipofuscin accumulation. Moreover, they, like senescent fibroblasts, are blocked preferentially in G1 as evident from DNA content measurements...

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Identifiers

PMID: 7664835
DOI: 10.1006/excr.1995.1305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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