Article
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?
Experimental cell research - 1 Sept 1995
von Zglinicki T, Saretzki G, Döcke W, Lotze C
Abstract excerpt
Mild oxidative stress as exerted by culture of human WI-38 fibroblasts under 40% oxygen partial pressure blocks proliferation irreversibly after one to three population doublings. Hyperoxically blocked cells are similar to senescent ones in terms of general morphology and lipofuscin accumulation....
Topics
- Aerobiosis
- Cell Cycle
- Cells, Cultured
- Cellular Senescence
- Fibroblasts
- Flow Cytometry
- Lipofuscin
- Microscopy, Electron
- Oligonucleotide Probes
- Oxidative Stress
- Oxygen
- Phenotype
- Ploidies
- Telomere