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Article

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence.

Journal of visualized experiments : JoVE - 12 Aug 2018

Kim Young Yeon, Um Jee-Hyun, Yun Jeanho

Abstract excerpt

Cellular senescence has been considered a state of irreversible growth arrest upon exhaustion of proliferative capacity or exposure to various stresses. Recent studies have extended the role of cellular senescence to various physiological processes, including development, wound healing, immune surveillance, and age-related tissue dysfunction. Although cell cycle arrest is a critical hallmark of cellular...

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PMID: 30148482
DOI: 10.3791/57890
PMCID: PMC6126784

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