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Article

MPer1 and mper2 are essential for normal resetting of the circadian clock.

Journal of biological rhythms - 1 Apr 2001

Albrecht U, Zheng B, Larkin D, Sun Z S, Lee C C

Abstract excerpt

Mammalian Per1 and Per2 genes are involved in the mechanism of the circadian clock and are inducible by light. A light pulse can evoke a change in the onset of wheel-running activity in mice by shifting the onset of activity to earlier times (phase advance) or later times (phase delays) thereby advancing or delaying the clock (clock resetting). To assess the role of mouse Per (mPer) genes in circadian clock...

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Identifiers

PMID: 11302552
DOI: 10.1177/074873001129001791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MPer1 and mper2 are essential for normal resetting of the circadian clock.PMID 11302552Read ↗

Light-induced phase shifts in mice lacking mPER1 or mPER2.Semantic proximity Read ↗

The mPer2 gene encodes a functional component of the mammalian circadian clock.Semantic proximity Read ↗

Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms.Semantic proximity Read ↗

High amplitude phase resetting in rev-erbalpha/per1 double mutant mice.Semantic proximity Read ↗

The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude.Semantic proximity Read ↗

Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock.Semantic proximity Read ↗

ORL1 receptor-mediated down-regulation of mPER2 in the suprachiasmatic nucleus accelerates re-entrainment of the circadian clock following a shift in the environmental light/dark cycle.Semantic proximity Read ↗

Robust circadian rhythmicity of Per1 and Per2 mutant mice in constant light, and dynamics of Per1 and Per2 gene expression under long and short photoperiods.Semantic proximity Read ↗

Photic entrainment of period mutant mice is predicted from their phase response curves.Semantic proximity Read ↗

Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice.Semantic proximity Read ↗

Loss of circadian rhythmicity in aging mPer1-/-mCry2-/- mutant mice.Semantic proximity Read ↗

Masking responses to light in period mutant mice.Semantic proximity Read ↗

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