Article
Functional Proteomics: Examining the Effects of Hypoxia on the Cytotrophoblast Protein Repertoire
8 Mar 2001
Abstract excerpt
The outcome of human pregnancy depends on the differentiation of cytotrophoblasts, specialized placental cells that physically connect the embryo/fetus to the mother. As cytotrophoblasts differentiate, they acquire tumor-like characteristics that enable them to invade the uterus. In a novel feedback loop, the increasingly higher levels of oxygen they encounter within the uterine wall influence their...
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