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Article

Microarray analysis of trophoblast differentiation: gene expression reprogramming in key gene function categories

17 Jul 2001

Abstract excerpt

Placental development results from a highly dynamic differentiation program. We used DNA microarray analysis to characterize the process by which human cytotrophoblast cells differentiate into syncytiotrophoblast cells in a purified cell culture system. Of 6,918 genes analyzed, 141 genes were induced and 256 were downregulated by more than 2-fold. Dynamically regulated genes were divided by the K-means algorithm...

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PMID: 11459926
DOI: 10.1152/physiolgenomics.2001.6.2.105

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