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Article

Hypoxia alters the epigenetic profile in cultured human placental trophoblasts

11 Jan 2013

Abstract excerpt

The mechanisms by which the placenta adapts to exogenous stimuli to create a stable and healthy environment for the growing fetus are not well known. Low oxygen tension influences placental function, and is associated with preeclampsia, a condition displaying altered development of placental trophoblast. We hypothesized that oxygen tension affects villous trophoblast by modulation of gene expression through DNA...

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Share to Epigenetics and DNA Methylation
Share to Pregnancy and preeclampsia studies
Share to Prenatal Screening and Diagnostics

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Identifiers

PMID: 23314690
DOI: 10.4161/epi.23400

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