Article

Maternal smoking in early pregnancy disrupts placental function through syncytiotrophoblast and macrophage dysregulation

2025-07-15

Abstract excerpt

<h4>Summary</h4> Smoking in pregnancy is the leading avoidable cause of gestational morbidity and mortality, causally linked to fetal growth restriction (FGR). The placenta, functional interface between mother and fetus is essential for healthy fetal development. For the first time, we studied cell type-resolved smoking effects on placental development at high molecular resolution using single-nucleus RNA sequenc...

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Literature Corpus work: 31d76750-08a9-572d-9708-65d3dc88a82a
DOI: 10.1101/2025.07.10.664172

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