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Article

Regulation of Human Placental Development by Oxygen Tension

12 Sept 1997

Abstract excerpt

Cytotrophoblasts, specialized placental cells, proliferate early in pregnancy and then differentiate into tumor-like cells that establish blood flow to the placenta by invading the uterus and its vasculature. In this study, cytotrophoblasts cultured under hypoxic conditions (2 percent oxygen), mimicking the environment near the uterine surface before 10 weeks of gestation, continued proliferating and...

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Identifiers

PMID: 9287221
DOI: 10.1126/science.277.5332.1669

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