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Article

Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia

23 Jun 2013

Abstract excerpt

During human pregnancy, a subset of placental cytotrophoblasts (CTBs) differentiates into cells that aggressively invade the uterus and its vasculature, anchoring the progeny and rerouting maternal blood to the placenta. In preeclampsia (PE), CTB invasion is limited, reducing placental perfusion and/or creating intermittent flow. This syndrome, affecting 4%-8% of pregnancies, entails maternal vascular alterations...

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PMID: 23934129
DOI: 10.1172/jci66966

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