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Novel genes associated with a placental phenotype in knockout mice also respond to cellular stressors in primary human trophoblasts.

Placenta - 1 Aug 2023

Kadife Elif, Harper Alesia, Chien Keegan, Lino Tu'uhevaha Kaitu'u, Brownfoot Fiona C

Abstract excerpt

INTRODUCTION: Placental insufficiency is a leading cause of intrauterine growth restriction, contributing to perinatal morbidity and mortality. The molecular regulation of placental development and what causes placental insufficiency is poorly understood. Recently, a panel of genes were found to cause significant placental dysmorphologies in mice with severely growth restricted off-spring. We aimed to assess...

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Fetal Growth Retardation
Hypoxia
Mice, Knockout
NIMA-Related Kinases
Placenta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37331027
DOI: 10.1016/j.placenta.2023.05.012

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