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Article

Aldehydes potentiate alpha(2)(I) collagen gene activity by JNK in hepatic stellate cells.

Free radical biology & medicine - 15 Apr 2001

Anania F A, Womack L, Jiang M, Saxena N K

Abstract excerpt

Hepatic stellate cells (HSCs) are responsible for type I collagen deposition in liver fibrosis that leads to cirrhosis. The purpose of this study was to examine potential molecular signals that lead to increased alpha(2)(I) collagen gene expression by acetaldehyde, the primary metabolite of alcohol and malondialdehyde (MDA), a lipid peroxidation product known to be associated with chronic liver injury. MDA and...

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Identifiers

PMID: 11295527
DOI: 10.1016/s0891-5849(01)00470-1
PMCID: PMC2927869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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