Article

<i>MyD88</i> deficiency modestly attenuates disease in a Leigh syndrome mouse model while enrofloxacin accelerates disease

2026-05-17

Abstract excerpt

Primary genetic mitochondrial diseases (GMDs) are a clinically and genetically diverse group of diseases estimated to impact over 1 in 4,000 individuals. Leigh syndrome (LS) is the most common pediatric presentation of GMD. LS typically presents within the first years of life and is a severe progressive multi-system disorder. Symmetric progressive inflammatory brain lesions are a defining feature of the disease. P...

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Literature Corpus work: d84f4d80-a311-5cbd-acaf-66e0806b1007
DOI: 10.64898/2026.05.13.724988

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