Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Highly efficient base excision repair (BER) in human and rat male germ cells.

Nucleic acids research - 15 Apr 2001

Olsen A K, Bjørtuft H, Wiger R, Holme J, Seeberg E, Bjørås M, Brunborg G

Abstract excerpt

The quality of germ cell DNA is critical for the fate of the offspring, yet there is limited knowledge of the DNA repair capabilities of such cells. One of the main DNA repair pathways is base excision repair (BER) which is initiated by DNA glycosylases that excise damaged bases, followed by incision of the generated abasic (AP) sites. We have studied human and rat methylpurine-DNA glycosylase (MPG), uracil-DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbon-Oxygen Lyases
Share to Cell Extracts
Share to Comet Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deoxyribonuclease IV (Phage T4-Induced)

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Share to N-Glycosyl Hydrolases

Share to Spermatids

Share to Uracil-DNA Glycosidase

Source

Open in PubMed Open full text

Identifiers

PMID: 11292851
DOI: 10.1093/nar/29.8.1781
PMCID: PMC31315

Genes

HAP1
MPG
UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Highly efficient base excision repair (BER) in human and rat male germ cells.PMID 11292851Read ↗

DNA damage in testicular germ cells and spermatozoa. When and how is it induced? How should we measure it? What does it mean?Semantic proximity Read ↗

Do heat stress and deficits in DNA repair pathways have a negative impact on male fertility?Semantic proximity Read ↗

The senescence-accelerated mouse prone 8 as a model for oxidative stress and impaired DNA repair in the male germ line.Semantic proximity Read ↗

Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement.Semantic proximity Read ↗

Male Rat Germ Cells Display Age-Dependent and Cell-Specific Susceptibility in Response to Oxidative Stress Challenges1Semantic proximity Read ↗

Fertilization stimulates 8-hydroxy-2′-deoxyguanosine repair and antioxidant activity to prevent mutagenesis in the embryoSemantic proximity Read ↗

OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culture†.Semantic proximity Read ↗

Impact of polymorphism in DNA repair genes OGG1 and XRCC1 on seminal parameters and human male infertility.Semantic proximity Read ↗

Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic CellsSemantic proximity Read ↗

Senescent males carry premutagenic lesions in spermSemantic proximity Read ↗

A single, mild, transient scrotal heat stress causes DNA damage, subfertility and impairs formation of blastocysts in miceSemantic proximity Read ↗

Deletion of Genes Implicated in Protecting the Integrity of Male Germ Cells Has Differential Effects on the Incidence of DNA Breaks and Germ Cell LossSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.