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OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culture†.

Biology of reproduction - 11 Mar 2021

Mori Yoshifumi, Ogonuki Narumi, Hasegawa Ayumi, Kanatsu-Shinohara Mito, Ogura Atsuo, Wang Yufeng, McCarrey John R, Shinohara Takashi

Abstract excerpt

Although reactive oxygen species (ROS) are required for spermatogonial stem cell (SSC) self-renewal, they induce DNA damage and are harmful to SSCs. However, little is known about how SSCs protect their genome during self-renewal. Here, we report that Ogg1 is essential for SSC protection against ROS. While cultured SSCs exhibited homologous recombination-based DNA double-strand break repair at levels comparable...

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PMID: 33252132
DOI: 10.1093/biolre/ioaa216

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