Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic Cells

23 Aug 2012

Abstract excerpt

Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have been shown to differentiate into primordial germ cells (PGCs) but not into spermatogonia, haploid spermatocytes, or spermatids. Here, we show that hESCs and hiPSCs differentiate directly into advanced male germ cell lineages, including postmeiotic, spermatid-like cells, in vitro without genetic manipulation. Furthermore, our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pluripotent Stem Cells Research
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22921399
DOI: 10.1016/j.celrep.2012.07.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic CellsPMID 22921399Read ↗

Generation of male differentiated germ cells from various types of stem cells.Semantic proximity Read ↗

A Novel Organoid Model of In Vitro Spermatogenesis Using Human Induced Pluripotent Stem CellsSemantic proximity Read ↗

Generation of spermatogonia from pluripotent stem cells in humans and non-human primatesSemantic proximity Read ↗

Efficient generation of functional haploid spermatids from human germline stem cells by three-dimensional-induced systemSemantic proximity Read ↗

Mesenchymal to Epithelial Transition Mediated by CDH1 Promotes Spontaneous Reprogramming of Male Germline Stem Cells to PluripotencySemantic proximity Read ↗

Reconstitution of prospermatogonial specification <i>in vitro</i> from human induced pluripotent stem cellsSemantic proximity Read ↗

DNA methylation imprinting marks and DNA methyltransferase expression in human spermatogenic cell stagesSemantic proximity Read ↗

Generation of Haploid Spermatids with Fertilization and Development Capacity from Human Spermatogonial Stem Cells of Cryptorchid PatientsSemantic proximity Read ↗

Valproic acid Promotes the in Vitro Differentiation of Human Pluripotent Stem Cells Into Spermatogonial Stem Cell-like CellsSemantic proximity Read ↗

M31, a murine homolog of Drosophila HP1, is concentrated in the XY body during spermatogenesis.Semantic proximity Read ↗

Differentiation of Peritubular Myoid-Like Cells from Human Induced Pluripotent Stem CellsSemantic proximity Read ↗

Direct Transdifferentiation of Stem/Progenitor Spermatogonia Into Reproductive and Nonreproductive Tissues of All Germ LayersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.