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Article

Impact of polymorphism in DNA repair genes OGG1 and XRCC1 on seminal parameters and human male infertility.

Andrologia - 1 Dec 2018

Garcia-Rodriguez Anaís, de la Casa Moises, Serrano Malena, Gosálvez Jamie, Roy Barcelona Rosa

Abstract excerpt

The DNA repair capacity in the mature spermatozoa is highly compromised due to the base-excision repair (BER) route being truncated. In the mature spermatozoa, only the first enzyme of the route (OGG1) is present. Consequently, reduced activity of the enzymes of the BER route both during spermatogenesis and in the mature spermatozoa may be detrimental for fertility. The objective of our study was to investigate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to X-ray Repair Cross Complementing Protein 1

Source

Identifiers

PMID: 30043545
DOI: 10.1111/and.13115

Genes

OGG1
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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