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Article

HNF-3 beta is essential for node and notochord formation in mouse development.

Cell - 26 Aug 1994

Ang S L, Rossant J

Abstract excerpt

HNF-3 beta, a member of the HNF-3/fork head family of transcription factors, is expressed in the node, notochord, floor plate, and gut in mouse embryos. A null mutation of this gene leads to embryonic lethality. The primary defect of HNF-3 beta -/- embryos is an absence of organized node and notochord formation, which leads to secondary defects in dorsal-ventral patterning of the neural tube. In contrast,...

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Source

Identifiers

PMID: 8069909
DOI: 10.1016/0092-8674(94)90522-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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