Article
HNF-3 beta is essential for node and notochord formation in mouse development.
Cell - 26 Aug 1994
Ang S L, Rossant J
Abstract excerpt
HNF-3 beta, a member of the HNF-3/fork head family of transcription factors, is expressed in the node, notochord, floor plate, and gut in mouse embryos. A null mutation of this gene leads to embryonic lethality. The primary defect of HNF-3 beta -/- embryos is an absence of organized node and noto...
Topics
- Animals
- Base Sequence
- Central Nervous System
- Chimera
- Crosses, Genetic
- DNA-Binding Proteins
- Digestive System
- Embryonic and Fetal Development
- Female
- Gastrula
- Genes, Lethal
- Hepatocyte Nuclear Factor 3-beta
- Male
- Mesoderm
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Notochord