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Article

Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility.

The Biochemical journal - 15 Apr 2001

Li S W, Arita M, Fertala A, Bao Y, Kopen G C, Långsjö T K, Hyttinen M M, Helminen H J, Prockop D J

Abstract excerpt

Transgenic mice were prepared with inactive alleles for procollagen N-proteinase (ADAMTS-2; where ADAMTS stands for a disintegrin and metalloproteinase with thrombospondin repeats). Homozygous mice were grossly normal at birth, but after 1-2 months they developed thin skin that tore after gentle handling. Although the gene was inactivated, a large fraction of the N-propeptides of type I procollagen in skin and...

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Identifiers

PMID: 11284712
DOI: 10.1042/0264-6021:3550271
PMCID: PMC1221736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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