Article
Transgenic mice that express a mini-gene version of the human gene for type I procollagen (COL1A1) develop a phenotype resembling a lethal form of osteogenesis imperfecta.
The Journal of biological chemistry - 5 Dec 1991
Khillan J S, Olsen A S, Kontusaari S, Sokolov B, Prockop D J
Abstract excerpt
A mini-gene version of the human gene for a pro-alpha 1(I) chain of type I procollagen (COL1A1) was prepared that contained -2.5 kilobases of the promoter region and the 5'- and 3'-ends of the gene but lacked a large central region containing 41 exons. The construct was modeled after a sporadic i...
Topics
- Animals
- Blotting, Western
- Cells, Cultured
- Cloning, Molecular
- Female
- Fibroblasts
- Humans
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Transgenic
- Organ Specificity
- Osteogenesis Imperfecta
- Phenotype
- Procollagen