Mice homozygous for a null mutation of activin beta B are viable and fertile.

doi:10.1016/0925-4773(94)90094-9

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Article

Mice homozygous for a null mutation of activin beta B are viable and fertile.

Mechanisms of development - 1 Jul 1994

Schrewe H, Gendron-Maguire M, Harbison M L, Gridley T

Abstract excerpt

We have made a null mutation in the mouse activin beta B gene by deleting the portion of the gene encoding the proteolytic cleavage site and the majority of the coding region for the mature processed protein. Mice homozygous for this mutation complete embryogenesis and are completely viable. Appr...

Topics

Activins
Adjuvants, Immunologic
Alleles
Animals
Base Sequence
Blotting, Southern
Cell Line
Embryo, Mammalian
Embryonic and Fetal Development
Female
Fertility
Genotype
Homozygote
Male
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Mutation

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