Article
Mice homozygous for a null mutation of activin beta B are viable and fertile.
Mechanisms of development - 1 Jul 1994
Schrewe H, Gendron-Maguire M, Harbison M L, Gridley T
Abstract excerpt
We have made a null mutation in the mouse activin beta B gene by deleting the portion of the gene encoding the proteolytic cleavage site and the majority of the coding region for the mature processed protein. Mice homozygous for this mutation complete embryogenesis and are completely viable. Approximately 40% of the homozygous mutant animals are born with open eyes. Aside from the incompletely penetrant eye...
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