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Article

Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43.

American journal of human genetics - 1 May 2001

Alam N A, Bevan S, Churchman M, Barclay E, Barker K, Jaeger E E, Nelson H M, Healy E, Pembroke A C, Friedmann P S, Dalziel K, Calonje E, Anderson J, August P J, Davies M G, Felix R, Munro C S, Murdoch M, Rendall J, Kennedy S, Leigh I M, Kelsell D P, Tomlinson I P, Houlston R S

Abstract excerpt

Dominant transmission of multiple uterine and cutaneous smooth-muscle tumors is seen in the disorder multiple leiomyomatosis (ML). We undertook a genomewide screen of 11 families segregating ML and found evidence for linkage to chromosome 1q42.3-q43 (maximum multipoint LOD score 5.40). Haplotype construction and analysis of recombinations permitted the minimal interval containing the locus, which we have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11283798
DOI: 10.1086/320124
PMCID: PMC1226106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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