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Article

A Role for BRCA1 in Uterine Leiomyosarcoma

20 Oct 2009

Abstract excerpt

Uterine leiomyosarcoma (ULMS) is a rare gynecologic malignancy with a low survival rate. Currently, there is no effective treatment for ULMS. Infrequent occurrences of human ULMS hamper the understanding of the initiation and progression of the disease, thereby limiting the ability to develop efficient therapies. To elucidate the roles of the p53 and BRCA1 tumor suppressor genes in gynecologic malignancies, we...

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PMID: 19843854
DOI: 10.1158/0008-5472.can-09-2543

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