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Article

Multiple Hits for the Association of Uterine Fibroids on Human Chromosome 1q43

14 Mar 2013

Abstract excerpt

Uterine leiomyomas (or fibroids) are the most common tumors in women of reproductive age. Early studies of two familial cancer syndromes, the multiple cutaneous and uterine leiomyomatosis (MCUL1), and the hereditary leiomyomatosis and renal cell cancer (HLRCC), implicated FH, a gene on chromosome 1q43 encoding the tricarboxylic acid cycle fumarate hydratase enzyme. The role of this metabolic housekeeping gene in...

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PMID: 23555580
DOI: 10.1371/journal.pone.0058399

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Multiple Hits for the Association of Uterine Fibroids on Human Chromosome 1q43PMID 23555580Read ↗

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Analysis of fumarate hydratase mutations in a population‐based series of early onset uterine leiomyosarcoma patientsSemantic proximity Read ↗

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Integrated genetic and clinical investigation of autosomal dominant hereditary uterine leiomyomas: genotype-phenotype correlation in a pakistani family.Semantic proximity Read ↗

Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors.Semantic proximity Read ↗

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