Article
The susceptibility of Mycobacterium tuberculosis to isoniazid and the Arg-->Leu mutation at codon 463 of katG are not associated.
Journal of clinical microbiology - 1 Apr 2001
van Doorn H R, Kuijper E J, van der Ende A, Welten A G, van Soolingen D, de Haas P E, Dankert J
Abstract excerpt
A mutation (CCG-->CTG [Arg-->Leu]) in codon 463 of katG (catalase peroxidase) of Mycobacterium tuberculosis has been found in isoniazid (INH)-resistant strains. A PCR restriction endonuclease analysis to detect this mutation was applied to 395 M. tuberculosis isolates from patients in The Netherlands. The proportion of isolates with a detectable mutation was 32% (32 out of 100) and 29% (85 out of 295) among...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.