Article
katG mutations in isoniazid-resistant Mycobacterium tuberculosis isolates recovered from Finnish patients.
Antimicrobial agents and chemotherapy - 1 Sept 1996
Marttila H J, Soini H, Huovinen P, Viljanen M K
Abstract excerpt
katG and inhA genes from isoniazid-resistant Mycobacterium tuberculosis strains isolated in Finland were examined by PCR or sequencing. By PCR, katG was not detected in 3 of 54 strains. Sequencing of katG from 13 strains showed small point mutations or insertions; a previously described mutation causing a Ser-to-Thr change at position 315 was found in 4 strains, and there were nine new missense mutations of katG....
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