Article
Effects of cytokines on microglial phenotypes and astroglial coupling in an inflammatory coculture model.
Glia - 1 Nov 2005
Hinkerohe Daniel, Smikalla Dirk, Haghikia Aiden, Heupel Katharina, Haase Claus G, Dermietzel Rolf, Faustmann Pedro M
Abstract excerpt
Cytokines play an important role in the onset, regulation, and propagation of immune and inflammatory responses within the central nervous system (CNS). The main source of cytokines in the CNS are microglial cells. Under inflammatory conditions, microglial cells are capable of producing pro- and antiinflammatory cytokines, which convey essential impact on the glial and neuronal environment. One paramount...
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