Article
Potential tumorigenic programs associated with TP53 mutation status reveal role of VEGF pathway.
British journal of cancer - 6 Nov 2012
Joshi H, Bhanot G, Børresen-Dale A-L, Kristensen V
Abstract excerpt
BACKGROUND: Targeting differentially activated or perturbed tumour pathways is the key idea in individualised cancer therapy, which is emerging as an important option in treating cancers with poor prognostic profiles. TP53 mutation status is known as a core determinant of survival in breast cancer. The pathways disrupted in association with TP53 mutation status in tumours are not well characterised. METHOD: In...
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