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Article

Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1.

American journal of physiology. Gastrointestinal and liver physiology - 1 Sept 2004

Wang Zhi, Fang Rixun, Olds Lynne C, Sibley Eric

Abstract excerpt

Lactase-phlorizin hydrolase gene expression is spatially restricted along the anterior-posterior gut axis. Lactase gene transcription is maximal in the distal duodenum and jejunum in adult mammals and is barely detectable in the proximal duodenum. By contrast, pancreatic duodenal homeobox-1 (PDX-1) protein is expressed maximally in the proximal duodenum. This study aimed to determine the role of PDX-1 in...

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Identifiers

PMID: 15107297
DOI: 10.1152/ajpgi.00011.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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