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SERTM2: a neuroactive player in the world of micropeptides

19 Mar 2025

Abstract excerpt

In this study, we analyze the long noncoding RNA, lncMN3, that is predominantly expressed in motor neurons and shows potential coding capabilities. Utilizing custom antibodies, we demonstrate the production of a lncMN3-derived type I transmembrane micropeptide, SERTM2. Patch-clamp experiments performed on both wild-type and SERTM2 knockout motor neurons, differentiated in vitro from mouse embryonic stem cells,...

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PMID: 40108405
DOI: 10.1038/s44319-025-00404-w

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