Article
Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2005
Syed Farhan A, Mödder Ulrike I L, Fraser Daniel G, Spelsberg Thomas C, Rosen Clifford J, Krust Andree, Chambon Pierre, Jameson J Larry, Khosla Sundeep
Abstract excerpt
UNLABELLED: ER alpha acts either through classical (ERE-mediated) or nonclassical (non-ERE) pathways. The generation of mice carrying a mutation that eliminates classical ER alpha signaling presents a unique opportunity to study the relative roles of these pathways in bone. This study defines the skeletal phenotype and responses to ovariectomy and estrogen replacement in these mice. INTRODUCTION: Estrogen...
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