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Article

JunB Is Involved in the Inhibition of Myogenic Differentiation by Bone Morphogenetic Protein-2

1 Jan 1998

Abstract excerpt

Bone morphogenetic proteins (BMPs) constitute a family of multifunctional growth and differentiation factors structurally related to transforming growth factor-beta. BMPs were first identified by their osteoinductive effects, inducing ectopic bone formation when implanted in skeletal muscle, and have an important role as regulators of skeletal development in vivo. In vitro, BMP-2 is able to transdifferentiate...

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Identifiers

PMID: 9417113
DOI: 10.1074/jbc.273.1.537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

JunB Is Involved in the Inhibition of Myogenic Differentiation by Bone Morphogenetic Protein-2PMID 9417113Read ↗

Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation.Semantic proximity Read ↗

Runx2 Is a Common Target of Transforming Growth Factor β1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12Semantic proximity Read ↗

JunB contributes to Id2 repression and the epithelial–mesenchymal transition in response to transforming growth factor–βSemantic proximity Read ↗

Defective endochondral ossification in mice with strongly compromised expression of JunB.Semantic proximity Read ↗

Identification of Potential Modifiers of Runx2/Cbfa1 Activity in C2C12 Cells in Response to Bone Morphogenetic Protein-7Semantic proximity Read ↗

Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible EnhancerSemantic proximity Read ↗

Promoter-specific trans-activation and inhibition mediated by JunB.Semantic proximity Read ↗

NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1Semantic proximity Read ↗

Induction of the AP-1 members c-Jun and JunB by TGF-β/Smad suppresses early Smad-driven gene activationSemantic proximity Read ↗

Characterization of a unique motif in LIM mineralization protein-1 that interacts with jun activation-domain-binding protein 1.Semantic proximity Read ↗

The Interferon-inducible p204 Protein Acts as a Transcriptional Coactivator of Cbfa1 and Enhances Osteoblast DifferentiationSemantic proximity Read ↗

AP-2 alpha suppresses skeletal myoblast proliferation and represses fibroblast growth factor receptor 1 promoter activity.Semantic proximity Read ↗

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