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Article

AFos dissociates cardiac myocyte hypertrophy and expression of the pathological gene program.

Circulation - 5 Apr 2005

Jeong Mark Y, Kinugawa Koichiro, Vinson Charles, Long Carlin S

Abstract excerpt

BACKGROUND: Although induction of activator protein-1 (AP-1) transcription factor activity has been observed in cardiac hypertrophy, a direct role for AP-1 in myocardial growth and gene expression remains obscure. METHODS AND RESULTS: Hypertrophy was induced in cultured neonatal rat cardiomyocytes with phenylephrine or overexpression of a constitutively active MAP3K, MKK6. In both treatment groups, induction of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15795322
DOI: 10.1161/01.CIR.0000160367.99928.87
PMCID: PMC1201436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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