Article
Impaired sodium excretion, decreased glomerular filtration rate and elevated blood pressure in endothelin receptor type B deficient rats.
Journal of molecular medicine (Berlin, Germany) - 1 Jan 2001
Hocher B, Dembowski C, Slowinski T, Friese S T, Schwarz A, Siren A L, Neumayer H H, Thöne-Reineke C, Bauer C, Nafz B, Ehrenreich H
Abstract excerpt
The renal endothelin (ET) system, particularly the ET type B receptor, has been implicated in the regulation of sodium excretion and glomerular filtration rate (GFR). We analyzed kidney morphology and function in a rat strain characterized by complete absence of a functional ETB receptor. Due to Hirschsprung's disease limiting lifetime in these rats, studies were performed in 23-day-old rats. Kidney size and...
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