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Nephron number, hypertension, and CKD: physiological and genetic insight from humans and animal models

28 Jan 2017

Abstract excerpt

The kidneys play a vital role in the excretion of waste products and the regulation of electrolytes, maintenance of acid–base balance, regulation of blood pressure, and production of several hormones. Any alteration in the structure of the nephron (basic functional unit of the kidney) can have a major impact on the kidney’s ability to work efficiently. Progressive decline in kidney function can lead to serious...

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PMID: 28130427
DOI: 10.1152/physiolgenomics.00098.2016

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