Article
Nephron number, renal function, and arterial pressure in aged GDNF heterozygous mice.
Hypertension (Dallas, Tex. : 1979) - 1 Feb 2003
Cullen-McEwen Luise A, Kett Michelle M, Dowling John, Anderson Warwick P, Bertram John F
Abstract excerpt
The loss of one allele for glial cell line-derived neurotrophic factor (GDNF) results in approximately 30% fewer but normal sized glomeruli in young mice. Low nephron number, inherited or acquired, has been linked to increased risk of development of hypertension and renal failure. This study examines whether GDNF heterozygous mice, with an inherent reduction in nephron number, demonstrate a deterioration in renal...
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