Article
Estimating mutation rate and generation time from longitudinal samples of DNA sequences.
Molecular biology and evolution - 1 Apr 2001
Fu Y X
Abstract excerpt
We present in this paper a simple method for estimating the mutation rate per site per year which also yields an estimate of the length of a generation when mutation rate per site per generation is known. The estimator, which takes advantage of DNA polymorphisms in longitudinal samples, is unbiased under a number of population models, including population structure and variable population size over time. We apply...
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