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Article

Coalescent estimates of HIV-1 generation time <i>in vivo</i>

2 Mar 1999

Abstract excerpt

The generation time of HIV Type 1 (HIV-1) in vivo has previously been estimated using a mathematical model of viral dynamics and was found to be on the order of one to two days per generation. Here, we describe a new method based on coalescence theory that allows the estimate of generation times to be derived by using nucleotide sequence data and a reconstructed genealogy of sequences obtained over time. The...

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Identifiers

PMID: 10051616
DOI: 10.1073/pnas.96.5.2187

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Source receipt: pubmed, retrieved 7 Sept 2026.

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