Article
Molecular clock-like evolution of human immunodeficiency virus type 1.
Virology - 10 Nov 2004
Liu Yi, Nickle David C, Shriner Daniel, Jensen Mark A, Learn Gerald H, Mittler John E, Mullins James I
Abstract excerpt
The molecular clock hypothesis states that the rate of nucleotide substitution per generation is constant across lineages. If generation times were equal across lineages, samples obtained at the same calendar time would have experienced the same number of generations since their common ancestor. However, if sequences are not derived from contemporaneous samples, differences in the number of generations may be...
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