Dates of HIV infection can be estimated for seroprevalent patients by coalescent analysis of serial next-generation sequencing data

Abstract excerpt

OBJECTIVE: To reconstruct dates of HIV infection by the coalescent analysis of longitudinal next-generation sequencing (NGS) data. DESIGN: The coalescent predicts the time that has elapsed since the most recent common ancestor (MRCA) of a population. Because HIV tends to undergo severe bottlenecks upon transmission, the MRCA may be a good predictor of the time of infection. NGS provides an efficient means for...

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