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Article

Population genetic estimation of the loss of genetic diversity during horizontal transmission of HIV-1.

BMC evolutionary biology - 23 Mar 2006

Edwards Charles T T, Holmes Edward C, Wilson Daniel J, Viscidi Raphael P, Abrams Elaine J, Phillips Rodney E, Drummond Alexei J

Abstract excerpt

BACKGROUND: Genetic diversity of the human immunodeficiency virus type 1 (HIV-1) population within an individual is lost during transmission to a new host. The demography of transmission is an important determinant of evolutionary dynamics, particularly the relative impact of natural selection and genetic drift immediately following HIV-1 infection. Despite this, the magnitude of this population bottleneck is...

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Identifiers

PMID: 16556318
DOI: 10.1186/1471-2148-6-28
PMCID: PMC1444934

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