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Article

Gradual adaptation of animal influenza A viruses to human-type sialic acid receptors

29 Mar 2023

Abstract excerpt

Influenza A viruses (IAVs) originating from animal reservoirs pose continuous threats to human health as demonstrated by the Spanish flu pandemic. Infection starts by attachment to host receptors, a crucial step that is targeted by immunological, prophylactic, and therapeutic intervention. Fine-tuning of virus hemagglutinin binding to host-specific receptor repertoires needs to remain balanced to...

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PMID: 37001333
DOI: 10.1016/j.coviro.2023.101314

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