Article
Differences in sialic acid-galactose linkages in the chicken egg amnion and allantois influence human influenza virus receptor specificity and variant selection.
Journal of virology - 1 Apr 1997
Ito T, Suzuki Y, Takada A, Kawamoto A, Otsuki K, Masuda H, Yamada M, Suzuki T, Kida H, Kawaoka Y
Abstract excerpt
Human influenza viruses are more efficiently isolated by inoculating patient samples into the amniotic rather than the allantoic cavity of embryonated chicken eggs. This type of cultivation selects virus variants with mutations around the hemagglutinin (HA) receptor binding site. To understand th...
Topics
- Allantois
- Animals
- Antigens, Viral
- Chick Embryo
- Chickens
- Directed Molecular Evolution
- Dogs
- Eggs
- Galactose
- Genetic Variation
- Glycoconjugates
- Hemagglutinin Glycoproteins, Influenza Virus
- Humans
- Influenza A virus