Article
Human Mycobacterium tuberculosis-reactive CD4+ T-cell clones: heterogeneity in antigen recognition, cytokine production, and cytotoxicity for mononuclear phagocytes.
Infection and immunity - 1 Aug 1991
Boom W H, Wallis R S, Chervenak K A
Abstract excerpt
CD4+ T cells regulate the protective immune response which follows exposure to Mycobacterium tuberculosis by activating macrophages through the cytokines the CD4+ T cells secrete. In addition CD4+ T cells have been shown to be directly cytotoxic for antigen-pulsed mononuclear phagocytes (monocytes-macrophages). To explore the functional interaction between mycobacterial antigen-specific CD4+ T cells and...
Topics
- Antigens, Bacterial
- CD4-Positive T-Lymphocytes
- Cell Division
- Clone Cells
- Cytokines
- Cytotoxicity, Immunologic
- Epitopes
- Flow Cytometry
- Humans
- Macrophages
- Monocytes