Article
Glycophorin A somatic cell mutation frequencies in Finnish reinforced plastics workers exposed to styrene.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 1996
Bigbee W L, Grant S G, Langlois R G, Jensen R H, Anttila A, Pfäffli P, Pekari K, Norppa H
Abstract excerpt
We have used the glycophorin A (GPA) in vivo somatic cell mutation assay to assess the genotoxic potential of styrene exposure in 47 reinforced plastics workers occupationally exposed to styrene and 47 unexposed controls matched for age, gender, and active smoking status. GPA variant erythrocyte frequencies (Vf), reflecting GPA allele loss (phi/N) and allele loss and duplication (N/N) somatic mutations arising in...
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