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Article

p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal.

EMBO reports - 1 Jan 2001

Zezula J, Casaccia-Bonnefil P, Ezhevsky S A, Osterhout D J, Levine J M, Dowdy S F, Chao M V, Koff A

Abstract excerpt

Differentiation of most cell types requires both establishment of G1 arrest and the induction of a program related to achieving quiescence. We have chosen to study the differentiation of oligodendrocyte cells to determine the role of p27 and p21 in this process. Here we report that both p27 and p21 are required for the appropriate differentiation of these cells. p27 is required for proper withdrawal from the cell...

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Identifiers

PMID: 11252720
DOI: 10.1093/embo-reports/kve008
PMCID: PMC1083805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal.PMID 11252720Read ↗

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