Article
Lack of replicative senescence in cultured rat oligodendrocyte precursor cells.
Science (New York, N.Y.) - 2 Feb 2001
Tang D G, Tokumoto Y M, Apperly J A, Lloyd A C, Raff M C
Abstract excerpt
Most mammalian somatic cells are thought to have a limited proliferative capacity because they permanently stop dividing after a finite number of divisions in culture, a state termed replicative cell senescence. Here we show that most oligodendrocyte precursor cells purified from postnatal rat optic nerve can proliferate indefinitely in serum-free culture if prevented from differentiating; various cell...
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