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Article

Age of onset and effect size in genome-wide association studies.

Birth defects research. Part A, Clinical and molecular teratology - 1 Nov 2012

Agopian A J, Eastcott Lisa M, Mitchell Laura E

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified many susceptibility loci for complex traits, but have not identified the majority of the genetic contribution to common diseases. We explored whether the magnitude of associations detected in GWAS and, therefore, the likelihood of detecting a significant association for a given sample size, is generally greater for childhood-onset traits (e.g.,...

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Identifiers

PMID: 22933422
DOI: 10.1002/bdra.23066
PMCID: PMC4219508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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