Article
On selecting markers for association studies: patterns of linkage disequilibrium between two and three diallelic loci.
Genetic epidemiology - 1 Jan 2003
Garner Chad, Slatkin Montgomery
Abstract excerpt
Association studies depend on linkage disequilibrium (LD) between a causative mutation and linked marker loci. Selecting markers that give the best chance of showing useful levels of LD with the causative mutation will increase the chances of successfully detecting an association. This report examines the variation in the extent of LD between a disease locus and one or two diallelic marker loci (termed single...
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