Article
The genetically isolated populations of Finland and sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes.
Nature genetics - 1 Jul 2000
Eaves I A, Merriman T R, Barber R A, Nutland S, Tuomilehto-Wolf E, Tuomilehto J, Cucca F, Todd J A
Abstract excerpt
The choice of which population to study in the mapping of common disease genes may be critical. Isolated founder populations, such as that found in Finland, have already proved extremely useful for mapping the genes for specific rare monogenic disorders and are being used in attempts to map the genes underlying common, complex diseases. But simulation results suggest that, under the common disease-common variant...
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