Article
A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation.
Biochemical and biophysical research communications - 1 Mar 2001
Ariyoshi N, Miyazaki M, Toide K, Sawamura Yi, Kamataki T
Abstract excerpt
A single nucleotide polymorphism (SNP) resulting in a substitution from Gln to His was found in exon 4 of the CYP2B6 gene in Japanese. The frequency of the variant allele was found to be 19.9%. The mutant- and the wild-type enzymes were expressed in Escherichia coli, and the effects of the single amino acid substitution on the catalytic activity were examined by investigating the kinetic profiles of...
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